RESEARCH
From Ion Channels to Translational Medicine
Our laboratory investigates how ion channels drive disease — and how to drug them.
Project 1
Ion Channel–Targeted Drug Discovery
Our longest-running program — and the one that has reached patients. Three IND-approved candidates for atopic dermatitis and allergic rhinitis have emerged from this pipeline, each built on ORAI1, TMEM16A, and TRPV3.
ORAI1
3 INDs
TMEM16A
Atopic Dermatitis
TRPV3
Allergic Rhinitis
ProJect 2
Structural & Computational Drug Screening
We identify drug-binding pockets on ion channel structures using ML-based molecular docking and molecular dynamics simulation — building the computational foundation for in silico screening of chemical libraries.
Molecular Docking
Binding site Mapping
MD simulation
in silico screening
Project 3
Sensory Neuron Physiology & Pain Biology
Sensory neurons in the dorsal root ganglion are the origin of chronic itch and pain. We profile natural compounds and small molecules that suppress DRG neuron excitability across multiple ion channel targets simultaneously.
Project 4
AAV-Based Gene Therapy
Delivering ion channel–modulating constructs directly to sensory neurons via AAV — for spatial, cell-type–specific relief of chronic neuropathic pain.
EMERGING