PUBLICATIONS
From Target to Therapeutic —
One Ion Channel at a Time.
98
peer-reviewed publications
Our laboratory has targeted ion channels in allergic disease and sensory disorders, with three IND-approved candidates to date.
Every project begins the same way: identify the channel, map the binding site, validate the mechanism, advance the candidate.
3
IND-approved candidates to date
9
patents (Korea/PCT/US)
Selected Publications — High-Impact Work
CANCER RESEARCH · 2025
IF 16.6 (2024 JCR)
Oncology #16/328
Nutrient Availability Dictates Cancer
Metabolism-Based Therapeutic Responses
to Non-oncology Drugs
Pyun WY et al., Nam JH (Co-corresponding)
BIOMEDICINE & PHARMACOTHERAPY · 2025
IF 7.5 (2024 JCR)
Pharmacology & Pharmacy #19/352
Polypharmacological effects of honokiol
on allergic rhinitis: Modulation of
TMEM16A, TRPV1, and calcium signaling
Phan HTL et al., Nam JH (Co-corresponding)
PNAS · 2024
IF 9.1 (2024 JCR)
Multidisciplinary Sciences #14/135
Distinct modulation of calcium-activated
chloride channel TMEM16A by a novel
drug-binding site
Roh JW et al., Nam JH (Co-corresponding)
PAIN · 2024
IF 5.5 (2024 JCR)
Anesthesiology #6/68
Physiological profiling of cannabidiol
reveals profound inhibition of
sensory neurons
Chahyadinata G et al., Nam JH (Co-first)
EXPERIMENTAL & MOLECULAR MEDICINE · 2023
IF 12.8 (2024 JCR)
Biochemistry & Molecular Biology #14/320
Overlooked KCNQ4 variants augment
the risk of hearing loss
Oh KS et al., Nam JH (Co-corresponding)
PHYTOMEDICINE · 2023
IF 8.3 (2024 JCR)
Integrative & Complementary Medicine #1/45
Multi-target modulation of ion channels
underlying the analgesic effects of
alpha-mangostin in dorsal root ganglion
neurons
Kim SE et al., Nam JH (Co-corresponding)
INTELLECTUAL PROPERTY
Patents
The laboratory actively seeks to translate fundamental ion channel research into clinical applications. Our intellectual property portfolio covers novel target identification, specific modulators, and therapeutic compositions for sensory and metabolic disorders.
6
KOREA
2
PCT
US (PENDING)
TOTAL
1
9
🇰🇷
KOREA
6 patents
01. Health functional composition for skin anti-aging extracted from Rhizomes of Cyperus rotundus
Reg. No. 1017318160000 · 2017.04.25
02. Health functional composition for skin anti-aging extracted from fruits of fennel
Reg. No. 1016891560000 · 2016.12.19
03. Composition for Preventing or Treating Allergic Rhinitis
Reg. No. 1022114240000 · 2021.01.28
04. A purified extract isolated from Agrimonia coreana NAKAI — composition for preventing or treating inflammation,
allergy and atopic dermatitis
Reg. No. 1024368630000 · 2022.08.23
05. Method of screening and evaluating for senile pruritus therapeutic candidates targeting TRPV3
Reg. No. 1028865800000 · 2025.11.11
06. Method of screening and evaluating for senile pruritus therapeutic candidates targeting TREK2
Reg. No. 1029249650000 · 2026.02.04
🌐
PCT (INTERNATIONAL)
2 patents
01. A composition comprising the compounds isolated from an extract of Agrimonia coreana NAKAI as an active ingredient
for preventing or treating immune-involved disease and the use thereof
WO2022086020A1 · 2022.04.28
02. A purified extract isolated from Agrimonia coreana NAKAI containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating
inflammation, allergy and atopic dermatitis
WO2022086019 · 2022.04.28
🇺🇸
UNITED STATES
1 patent
01. A purified extract isolated from Agrimonia coreana NAKAI containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and atopic dermatitis
US20230381261 · 2023.11.30
Pending
RECENT PUBLICATIONS
2023 — Present
Selected publications from the past five years. For the full list, see Google Scholar.
2025
1
CANCER RESEARCH
Nutrient Availability Dictates Cancer Metabolism-Based Therapeutic Responses to Non-oncology Drugs
Pyun WY et al., Nam JH
CORRESPONDING
PubMed →
2
BIOMEDICINE & PHARMACOTHERAPY
Polypharmacological effects of honokiol on allergic rhinitis: Modulation of TMEM16A, TRPV1, and calcium signaling
Phan HTL et al., Nam JH
CORRESPONDING
PubMed →
3
ANIMAL CELLS AND SYSTEMS
Scutellaria baicalensis extracts alleviate zymosan-induced irritable bowel syndrome symptoms by modulating inflammation and ion channel activity
Choi NR et al., Nam JH
4
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Activation of transient receptor potential vanilloid 3 is required for keratinocyte differentiation and epidermal barrier formation
Chung EDS et al., Nam JH
CORRESPONDING
2024
5
PNAS
Distinct modulation of calcium-activated chloride channel TMEM16A by a novel drug-binding site
Roh JW et al., Nam JH
CORRESPONDING
PubMed →
6
BIOCHEMICAL PHARMACOLOGY
Intermediate conductance calcium-activated potassium channel (KCa3.1) in cancer: Emerging roles and therapeutic potentials
Van NTH, Nam JH
CORRESPONDING
7
CHEMMEDCHEM
Unraveling the molecular reason of opposing effects of α-mangostin and norfluoxetine on TREK-2 at the same binding site
Kim G et al., Nam JH
CORRESPONDING
8
PAIN
Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons
Chahyadinata G†, Nam JH†, Battenberg A, Wainger BJ
CO-FIRST
9
PHARMACEUTICALS
Therapeutic effects and mechanisms of gintonin in irritable bowel syndrome and its relationship with TRPV1, TRPV4, and NaV1.5
Choi NR et al., Nam JH
10
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Agrimonia coreana Extract Exerts Its Therapeutic Effect through CRAC Channel Inhibition for Atopic Dermatitis Treatment
Kim J et al., Nam JH
11
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Regulation of T Lymphocyte Functions through Calcium Signaling Modulation by Nootkatone
Lee JM et al., Nam JH
12
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Inhibition of Ca²⁺-permeable TRPV3 and inflammatory cytokine release by honokiol and magnolol in human epidermal keratinocytes
Thi HD et al., Nam JH
CORRESPONDING
13
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Challenges in the Therapeutic Targeting of KCa Channels: From Basic Physiology to Clinical Applications
Van NTH et al., Nam JH
CORRESPONDING
2023
14
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Anti-Inflammatory Effects of Alphitolic Acid Isolated from Agrimonia coreana Nakai Extracts via Inhibition of ICRAC Activity in T Cells
Park SJ et al., Nam JH
15
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes
Dang TH et al., Nam JH
CORRESPONDING
16
JOURNAL OF ETHNOPHARMACOLOGY
Banhasasim-tang relieves irritable bowel syndrome symptoms via modulation of TRPA1, NaV1.5 and NaV1.7 channels
Choi NR et al., Nam JH
CORRESPONDING
17
PHYTOMEDICINE
Multi-target modulation of ion channels underlying the analgesic effects of α-mangostin in dorsal root ganglion neurons
Kim SE et al., Nam JH
CORRESPONDING
18
MARINE DRUGS
Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology
Kim SE et al., Nam JH
CORRESPONDING
19
EXPERIMENTAL & MOLECULAR MEDICINE
Overlooked KCNQ4 variants augment the risk of hearing loss
Oh KS et al., Nam JH
CORRESPONDING
20
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Inhibition of ANO1 by Cis- and Trans-Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells
Jeon D et al., Nam JH